CPT® Code 88269

Chromosome analysis is a laboratory procedure that examines the genetic material within cells to identify any chromosomal abnormalities. This specific analysis, coded as CPT® 88269, is performed on amniotic fluid cells collected during an amniocentesis procedure. The analysis is particularly relevant for patients who may be at increased risk for chromosomal disorders due to factors such as advanced maternal age, abnormal findings from prenatal ultrasounds, or abnormal results from maternal blood screenings. Additionally, it is indicated for individuals with a history of a previous child with a chromosomal anomaly, known familial chromosome rearrangements, or recognized familial genetic disorders. The process involves culturing the amniotic fluid cells, counting cells from 6 to 12 colonies, and performing one karyotype analysis with banding techniques. Karyotyping assesses the number, size, and shape of chromosomes, while banding techniques, such as Giemsa banding, allow for the identification of specific chromosomal structures and abnormalities. Normal karyotypes are characterized by 46 chromosomes, with females typically having 46 XX and males having 46 XY configurations.