CPT® Code 88273

The CPT® Code 88273 refers to a laboratory test that focuses on molecular cytogenetics, specifically utilizing chromosomal in situ hybridization (CISH) to analyze a sample of 10 to 30 cells. This procedure is essential for identifying chromosomal abnormalities, particularly microdeletions, which are small deletions of chromosomal material that can involve one or more genes and are often linked to various congenital anomalies. The test is typically performed on blood or bone marrow samples, which are obtained through a venipuncture or bone marrow aspiration, both of which are separately reportable procedures. The analysis aims to provide insights into the structure and functional organization of chromosomes, as well as to detect derivatives and markers such as small supernumerary marker chromosomes (sSMCs) and chromosomal exchange material, which can be identified through G-banded chromosome analysis. The results of this test can help in diagnosing several genetic conditions, including but not limited to Angelman syndrome, Prader-Willi syndrome, and Williams syndrome, among others. By analyzing the specified number of cells, this procedure enhances the understanding of chromosome biology and aids in the identification of genetic disorders associated with chromosomal abnormalities.