CPT® Code 88280

The CPT® Code 88280 refers to a laboratory procedure known as chromosome analysis, specifically for additional karyotypes. Karyotyping is a critical diagnostic tool that involves the examination of the structure, number, and configuration of chromosomes within a cell. This analysis is essential for understanding genetic information that influences inherited traits, growth patterns, development, and overall bodily functions. Typically, human cells contain 23 pairs of chromosomes, which include 22 pairs of autosomes and one pair of sex chromosomes. The procedure can involve various sample types, including chorionic villi or amniotic fluid for fetal genetic analysis, as well as whole blood for genetic testing across all age groups. In cases of hematologic or lymphoid diseases, such as leukemia, lymphoma, myeloma, and refractory anemia, samples may be taken from white blood cells (lymphocytes) or bone marrow. The collection of these samples is performed through specific procedures like venipuncture, bone marrow aspiration, amniocentesis, or chorionic villus sampling. Once the samples are obtained, the cells are cultured, and the chromosomes are isolated, fixed onto slides, and stained for visualization. The resulting microphotographs allow for the arrangement of chromosomes from smallest to largest, with matching pairs oriented vertically. A specialist then analyzes this arrangement to identify any chromosomal abnormalities, such as trisomy, monosomy, deletions, duplications, translocations, and other genetic rearrangements, culminating in a comprehensive written report of the findings. The use of code 88280 is specifically designated for each additional karyotype that is studied during this analysis.