CPT® Code 88341

Add-On Code

Immunohistochemistry or immunocytochemistry, per specimen; each additional single antibody stain procedure (List separately in addition to code for primary procedure)

Immunohistochemistry or immunocytochemistry is a laboratory technique used to identify specific antigens in cells within a specimen. This process involves the use of antibodies that are specifically designed to bind to these antigens, allowing for the visualization of their presence in various types of samples, including tissue blocks, brushed cell samples, blood smears, or fine needle biopsies (FNB). The specimens are prepared for examination by placing them on glass slides that have been fixed with a commercially available antibody. Following this, enzymes and/or special stains are applied to the slides, which facilitate the detection of the antigens. The changes observed in the cells can provide critical information regarding the antigenic profile of morphologically undifferentiated cells, which is essential in diagnosing malignant neoplasms. In this context, the coding for immunohistochemistry procedures is structured to differentiate between the primary and additional antibody stain procedures. Specifically, CPT® Code 88342 is utilized for the first identifiable single antibody stain per slide, while CPT® Code 88341 is designated for each additional single antibody stain performed. Furthermore, when multiple separately identifiable antibodies are applied to the same slide, CPT® Code 88344 is used. This structured coding system ensures accurate billing and documentation for the various antibody staining procedures performed in the laboratory.