CPT® Code 88361

Morphometric analysis, tumor immunohistochemistry (eg, Her-2/neu, estrogen receptor/progesterone receptor), quantitative or semiquantitative, per specimen, each single antibody stain procedure; using computer-assisted technology

The CPT® Code 88361 refers to a specialized laboratory test known as morphometric analysis, which is performed on tumor specimens using immunohistochemistry (IHC). This analysis focuses on the morphometric characteristics of tumor cells, which includes evaluating various cellular features such as size, shape, and the structural attributes of both the cell and its nucleus. Additionally, it involves determining the nucleus-to-cytoplasm ratio and identifying specific DNA or RNA markers that are crucial for understanding the tumor's biological behavior. Common markers analyzed through this technique include Her-2/neu, estrogen receptor (ER), progesterone receptor (PR), and others like Ki-67, p53, and CD34, among others. The results of morphometric analysis can provide valuable prognostic information regarding the likelihood of tumor recurrence and the potential response to therapeutic interventions. The tissue sample for this analysis is typically obtained through a biopsy or excision, which is reported separately. In some cases, cells may be collected via fine needle aspiration. Once the sample is obtained, it is stained and examined microscopically by a pathologist, often with the assistance of computer software that enhances the analysis through digital cellular imaging. This code specifically applies to IHC studies that utilize computer-assisted technology, distinguishing it from manual procedures coded under 88360.