CPT® Code 88380

Microdissection is a specialized technique used to isolate specific cells from a tissue sample for further analysis. In the context of CPT® Code 88380, this procedure employs laser capture microdissection, which allows for precise targeting of cells that have been microscopically identified as relevant for study. The process begins with the preparation of a thin section of tissue, which is then placed under a microscope. A transfer film is applied to this section, enabling the pathologist to visualize and select tiny clusters of cells that are of interest. Once the target cells are identified, a pulsed laser beam is directed at the transfer film, which fuses with the selected cells. This fusion allows for the removal of the cells from the tissue section, facilitating their analysis. The ability to isolate specific cells is crucial for studying disease processes at a cellular level, as it enables comparisons between abnormal or neoplastic cells and normal tissue. This information can be vital in determining appropriate treatment options for patients. In contrast, CPT® Code 88381 describes a manual method of microdissection, where selected cells are separated using traditional tools like a razor blade or scalpel under a dissecting microscope.