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Official Description

Immune globulin (SCIg), human, for use in subcutaneous infusions, 100 mg, each

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Immune globulins are specialized immunizing agents that provide effective, short-term, passive immunity by delivering antibodies directly into the recipient's system. Unlike active immunization, where the body's immune system is stimulated to produce its own antibodies, passive immunity involves the administration of pre-formed antibodies. This method of protection is particularly beneficial for individuals who may have compromised immune systems or are at increased risk of infections. The immune globulin used in this context is derived from a concentrated solution of antibodies that are pooled from the blood of multiple donors, ensuring a broad spectrum of antibody coverage. The subcutaneous administration of human immune globulin (SCIg) is specifically designed to prevent or mitigate the severity of certain infections in vulnerable patients. Additionally, SCIg is utilized in the management of various medical conditions, including immune system deficiencies, thrombocytopenia, and Kawasaki syndrome. The CPT® Code 90284 specifically reports the administration of human immune globulin for subcutaneous infusion, with each unit representing 100 mg of the product used, thereby facilitating accurate coding and billing for this therapeutic intervention.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Immune globulin (SCIg) is indicated for use in various clinical scenarios where passive immunity is beneficial. The following conditions and situations warrant the administration of this therapeutic agent:

  • Prevention of Infections SCIg is utilized to prevent or reduce the severity of certain infections in patients who are at risk due to compromised immune systems.
  • Immune System Disorders It is used to treat patients with immune system problems, providing necessary antibodies to help bolster their immune response.
  • Thrombocytopenia SCIg can be indicated for patients suffering from thrombocytopenia, a condition characterized by low platelet counts, which can lead to increased bleeding risks.
  • Kawasaki Syndrome This therapy is also indicated in the treatment of Kawasaki syndrome, a condition that primarily affects children and can lead to inflammation of blood vessels.

2. Procedure

The procedure for administering immune globulin (SCIg) involves several key steps to ensure safe and effective delivery of the therapy. Each step is critical for achieving the desired therapeutic outcomes.

  • Step 1: Patient Assessment Prior to administration, a thorough assessment of the patient’s medical history and current health status is conducted. This includes evaluating any previous reactions to immune globulin products and determining the appropriateness of SCIg therapy based on the patient's specific condition.
  • Step 2: Preparation of the Product The immune globulin product is prepared according to the manufacturer's instructions. This may involve allowing the solution to reach room temperature and ensuring that it is free from particulate matter or discoloration before use.
  • Step 3: Administration Technique The immune globulin is administered subcutaneously, typically in multiple sites to minimize discomfort and enhance absorption. The healthcare provider will select appropriate injection sites, often in the abdomen or thigh, and use aseptic technique to prevent infection.
  • Step 4: Monitoring After administration, the patient is monitored for any immediate adverse reactions or side effects. Vital signs may be checked, and the patient is observed for signs of allergic reactions or infusion-related complications.

3. Post-Procedure

Following the administration of immune globulin (SCIg), patients may experience some mild side effects, such as local site reactions, including redness or swelling. It is important for healthcare providers to provide post-procedure care instructions, which may include advising patients to monitor for any unusual symptoms or reactions in the days following the infusion. Patients should be informed about the signs of potential adverse effects, such as fever, rash, or difficulty breathing, and instructed to seek medical attention if these occur. Additionally, follow-up appointments may be scheduled to assess the effectiveness of the treatment and to determine if further doses are necessary based on the patient's ongoing health needs.

Short Descr HUMAN IG SC
Medium Descr IMMUNE GLOBULIN HUMAN SUBQ INFUSION 100 MG EA
Long Descr Immune globulin (SCIg), human, for use in subcutaneous infusions, 100 mg, each
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) P6D - Minor procedures - other (non-Medicare fee schedule)
MUE 0
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2011-01-01 Changed Short description changed.
2008-01-01 Added First appearance in code book in 2008.
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