CPT® Code 90378

The CPT® Code 90378 refers to a specific immunizing agent known as the respiratory syncytial virus (RSV) monoclonal antibody, which is a recombinant product intended for intramuscular use. This monoclonal antibody is designed to provide passive immunity against RSV, a virus that can cause severe respiratory infections, particularly in infants and young children. The antibody works by neutralizing the virus, thereby helping to prevent infection in high-risk populations. The production of this monoclonal antibody utilizes advanced recombinant DNA technology, which combines sequences from both murine (mouse) and human antibodies to create a product that is effective in conferring immunity. The administration of this antibody is typically done through an intramuscular injection, and it is recommended to be given on a monthly basis to infants who are at high risk for RSV infection. These high-risk infants include those who are premature, those with underlying conditions that compromise pulmonary function, and those with congenital heart disease. The dosage of the monoclonal antibody is determined based on the infant's weight, ensuring that each patient receives an appropriate amount of the medication. It is important to note that when billing for this service, the code 90378 should be reported for each 50 mg dose of the RSV recombinant monoclonal antibody administered intramuscularly, specifically indicating that it is the recombinant globulin product being reported.