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Official Description

Influenza virus vaccine, quadrivalent (qIRV), mRNA; 60 mcg/0.5 mL dosage, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90638 refers to a specific formulation of the influenza virus vaccine, which is classified as a quadrivalent mRNA vaccine. This vaccine is designed to provide immunity against influenza diseases caused by two subtypes of influenza A viruses and two types of influenza B viruses that are included in the vaccine composition. The term "quadrivalent" indicates that the vaccine targets four different strains of the influenza virus, enhancing its effectiveness in preventing influenza infections during the flu season. The use of messenger RNA (mRNA) technology in this vaccine represents a significant advancement in vaccine development. Unlike traditional vaccines that may use inactivated or weakened forms of the virus, mRNA vaccines utilize synthetic mRNA that encodes a portion of the viral protein. This approach stimulates the immune system to recognize and respond to the virus without exposing the individual to the actual virus itself. One of the key advantages of mRNA vaccines is their ability to be rapidly adapted to match the circulating strains of influenza, which can vary from year to year. This flexibility allows for a more timely and effective response to emerging influenza strains, potentially leading to higher vaccination efficacy. The specific dosage for CPT® Code 90638 is 60 mcg per 0.5 mL, intended for intramuscular use. It is important to note that the administration of the vaccine is reported separately, and for a lower dosage of 30 mcg per 0.5 mL, CPT® Code 90637 should be used.

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