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Official Description

Influenza vaccine, inactivated (IIV), subunit, adjuvanted, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90653 refers to an inactivated influenza vaccine (IIV) that is subunit and adjuvanted, specifically designed for intramuscular use. Vaccines, unlike immune globulins that provide short-term, passive immunity, are intended to provide active, long-term immunity. This is achieved by exposing the recipient's immune system to modified versions of specific viruses or bacteria, prompting the immune system to produce its own antibodies against these pathogens. The body retains a memory of how to produce these antibodies, enabling a quicker and more effective response upon subsequent exposures to the same antigens. The influenza vaccine is typically developed using embryonated chicken eggs, where the virus is cultivated, harvested, and then inactivated using formaldehyde to ensure it cannot cause disease. Subunit vaccines, such as this one, contain only the essential antigens that are most effective in stimulating the immune response. These antigens are identified and isolated through laboratory processes, which may involve growing the virus and using chemical methods to extract the necessary components. Alternatively, recombinant DNA technology can be employed to produce these antigens. After the subunit vaccine is created, an adjuvant is incorporated to enhance the immune response further. The inactivated influenza vaccine (IIV) is administered via intramuscular injection, and this method of administration is reported separately in medical coding.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The inactivated influenza vaccine (IIV), as represented by CPT® Code 90653, is indicated for the prevention of influenza virus infection. It is particularly recommended for individuals who are at higher risk of developing complications from influenza, including but not limited to:

  • High-Risk Populations: Individuals with chronic health conditions, such as asthma, diabetes, or heart disease, who may experience severe illness if infected with the influenza virus.
  • Older Adults: Individuals aged 65 years and older, who are more susceptible to severe influenza-related complications.
  • Healthcare Workers: Those who work in healthcare settings and may be exposed to influenza viruses, thereby protecting both themselves and their patients.
  • Pregnant Women: Pregnant individuals, as they are at increased risk for severe illness from influenza and can also pass antibodies to their infants.

2. Procedure

The administration of the inactivated influenza vaccine (IIV) involves several key procedural steps to ensure safety and efficacy:

  • Step 1: Preparation of the Vaccine The vaccine is prepared by ensuring that it is stored at the appropriate temperature and is not expired. The vial is inspected for any particulate matter or discoloration before use.
  • Step 2: Patient Assessment Prior to administration, the healthcare provider assesses the patient’s medical history, including any allergies, previous reactions to vaccines, and current health status to determine eligibility for vaccination.
  • Step 3: Site Selection and Cleaning The healthcare provider selects an appropriate site for intramuscular injection, typically the deltoid muscle of the upper arm. The site is then cleaned with an antiseptic wipe to reduce the risk of infection.
  • Step 4: Administration of the Vaccine The vaccine is drawn into a sterile syringe, and the needle is inserted into the muscle at a 90-degree angle. The vaccine is then injected slowly and steadily.
  • Step 5: Post-Administration Care After the injection, the healthcare provider observes the patient for a brief period to monitor for any immediate adverse reactions. The patient is provided with information regarding potential side effects and the importance of follow-up vaccinations if applicable.

3. Post-Procedure

Post-procedure care for the inactivated influenza vaccine (IIV) includes monitoring the patient for any immediate adverse reactions, such as allergic responses or injection site reactions. Patients are typically advised to rest and can resume normal activities unless otherwise directed. Common side effects may include soreness at the injection site, mild fever, or fatigue, which usually resolve within a few days. It is important for patients to be informed about the signs of more serious reactions and to seek medical attention if they experience difficulty breathing, swelling of the face or throat, or a rapid heartbeat. Additionally, patients should be encouraged to keep track of their vaccination history for future reference and to ensure they receive the vaccine annually, as influenza viruses can change from year to year.

Short Descr IIV ADJUVANT VACCINE IM
Medium Descr IIV ADJUVANTED VACCINE FOR INTRAMUSCULAR USE
Long Descr Influenza vaccine, inactivated (IIV), subunit, adjuvanted, for intramuscular use
Related Drugs FLUAD
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GW Service not related to the hospice patient's terminal condition
JZ Zero drug amount discarded/not administered to any patient
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
SL State supplied vaccine
SQ Item ordered by home health
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2015-11-24 Changed FDA Approval
2015-07-01 Changed Description Changed. FDA Approval Pending.
2013-01-01 Added Added
1991-12-31 Deleted Code deleted.
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