CPT® Code 90653

The CPT® Code 90653 refers to an inactivated influenza vaccine (IIV) that is subunit and adjuvanted, specifically designed for intramuscular use. Vaccines, unlike immune globulins that provide short-term, passive immunity, are intended to provide active, long-term immunity. This is achieved by exposing the recipient's immune system to modified versions of specific viruses or bacteria, prompting the immune system to produce its own antibodies against these pathogens. The body retains a memory of how to produce these antibodies, enabling a quicker and more effective response upon subsequent exposures to the same antigens. The influenza vaccine is typically developed using embryonated chicken eggs, where the virus is cultivated, harvested, and then inactivated using formaldehyde to ensure it cannot cause disease. Subunit vaccines, such as this one, contain only the essential antigens that are most effective in stimulating the immune response. These antigens are identified and isolated through laboratory processes, which may involve growing the virus and using chemical methods to extract the necessary components. Alternatively, recombinant DNA technology can be employed to produce these antigens. After the subunit vaccine is created, an adjuvant is incorporated to enhance the immune response further. The inactivated influenza vaccine (IIV) is administered via intramuscular injection, and this method of administration is reported separately in medical coding.