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A trivalent, split virus, preservative-free influenza vaccine product for intradermal use is provided under CPT® Code 90654. This vaccine is designed to stimulate the immune system to produce its own antibodies against specific strains of the influenza virus, thereby providing active, long-term immunity. Unlike immune globulins, which offer short-term, passive immunity, vaccines like this one expose the recipient's immune system to altered versions of the virus, prompting a robust immune response. The body retains a memory of how to produce these antibodies, ensuring a quicker and more effective response upon subsequent exposures to the virus.
The term "preservative-free" indicates that the formulation does not contain the preservative thimerosal, or contains only trace amounts of it. The FDA recognizes both thimerosal-free and thimerosal-reduced formulations as preservative-free, and they are labeled accordingly. This vaccine is specifically administered via intradermal injection, which is a distinct procedure that must be reported separately. The production of this influenza vaccine involves the use of embryonated chicken eggs, where the virus is harvested, inactivated with formaldehyde, concentrated, purified, and chemically disrupted to create a split virus. The trivalent formulation includes two different strains of influenza type A and one strain of influenza type B, ensuring broad protection against circulating influenza viruses.
© Copyright 2026 Coding Ahead. All rights reserved.
The influenza virus vaccine, trivalent (IIV3), split virus, preservative-free, for intradermal use is indicated for the prevention of influenza disease caused by the specific strains of the virus included in the vaccine formulation. The vaccine is recommended for individuals who are at risk of influenza complications, including but not limited to:
The administration of the influenza virus vaccine involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine. Each step is critical to the overall success of the vaccination process.
Post-procedure care for the influenza vaccine involves monitoring the patient for any immediate adverse reactions, such as redness, swelling, or pain at the injection site. Patients are typically advised to remain in the healthcare setting for a short period after vaccination to ensure they do not experience any severe allergic reactions. Additionally, patients should be informed about common side effects, which may include mild fever, fatigue, or muscle aches, and are encouraged to report any unusual symptoms. It is also important to remind patients that the vaccine takes about two weeks to provide optimal protection against influenza, and they should continue to practice preventive measures, such as hand hygiene and avoiding close contact with sick individuals, during this period.
| Short Descr | FLU VACC IIV3 NO PRESERV ID | Medium Descr | INFLUENZA VACC IIV3 SPLIT VIRUS PRSRV FREE ID | Long Descr | Influenza virus vaccine, trivalent (IIV3), split virus, preservative-free, for intradermal use | Related Drugs | FLUZONE Intradermal | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product | Type of Service (TOS) | V - Pneumococcal/Flu Vaccine | Berenson-Eggers TOS (BETOS) | O1G - Immunizations/Vaccinations | MUE | Not applicable/unspecified. | CCS Clinical Classification | 228 - Prophylactic vaccinations and inoculations |
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| 2024-12-31 | Deleted | Code Deleted. See 90653, 90655, 90656, 90657, 90658, 90660, 90661, 90662, 90664, 90666, 90667, 90668, 90672, 90673, 90674, 90682, 90685, 90686, 90687, 90688, 90689, 90694, 90756 |
| 2015-01-01 | Changed | Description Changed |
| 2012-01-01 | Added | First appearance in code book. |
| 2011-01-01 | Added | Released 2010-07-01. Implemented 2011-01-01 |
| 1991-12-31 | Deleted | Code deleted. |
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