© Copyright 2026 American Medical Association. All rights reserved.
A hemoperfusion procedure, as defined by CPT® Code 90997, involves the use of activated charcoal or resin to effectively remove harmful substances from the bloodstream. This medical intervention is particularly crucial for patients who have ingested drugs, poisons, or other toxic agents that pose a risk to kidney function. Additionally, hemoperfusion serves to eliminate waste products from the blood in individuals suffering from kidney disease, thereby aiding in the management of their condition. Furthermore, this procedure is utilized as a supportive treatment for patients with liver failure, especially in the context of liver transplantation, both prior to and following the surgical procedure. Hemoperfusion is distinguished from other blood filtration techniques, such as hemodialysis, by its ability to process a larger volume of blood—exceeding 300 mL per minute—making it a more efficient option for toxin clearance. The procedure involves the placement of two catheters in the patient's arm: one catheter is inserted into an artery, while the other is positioned in a nearby vein. These catheters are connected via plastic tubing, facilitating the removal of blood from the body. The extracted blood is then directed through a specialized hemoperfusion system, where it flows over a column or cartridge filled with activated charcoal or resin. This system effectively traps toxic molecules or particles, resulting in cleansed blood that is subsequently returned to the body through the venous access site.
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