© Copyright 2026 American Medical Association. All rights reserved.
Percutaneous transluminal coronary lithotripsy (PTCL), commonly referred to as intravascular lithotripsy (IVL), is a specialized medical procedure that utilizes ultrasound shock waves to effectively break down calcium deposits located within a coronary artery. This innovative technique is particularly beneficial in cases where traditional methods, such as high-pressure balloon angioplasty or atherectomy, may not yield successful results due to the presence of severely calcified plaque. The procedure is typically performed in conjunction with other interventions, such as balloon angioplasty and stent placement, to enhance the overall effectiveness of coronary artery treatment.
The concept of IVL is derived from the established practice of using acoustic pressure waves to fragment kidney stones, demonstrating its versatility in treating calcified lesions within the cardiovascular system. One of the key advantages of IVL is its ability to minimize injury to the surrounding coronary artery tissue, thereby reducing the risk of complications such as distal embolization, which can occur with more invasive debulking techniques. However, it is important to note that IVL is not suitable for all patients; specifically, it cannot be performed if the clinician is unable to pass a 0.014-inch guidewire across the calcified lesion, nor is it indicated for the treatment of restenosis within a stent.
Prior to the initiation of the IVL procedure, clinicians utilize percutaneous angiography to identify and measure the target lesions, ensuring precise treatment. The IVL procedure involves the use of a specialized catheter, typically 12 mm in diameter, which contains a disposable ultrasound core enclosed within a balloon. This catheter is advanced along a 0.014-inch guidewire to the site of calcification. Once positioned, the balloon is inflated to a pressure of 4 atmospheres, allowing the IVL device to emit a series of pulsed sound waves through its transmitters, effectively targeting the calcium deposits. Following the treatment, the balloon is deflated to allow any resulting bubbles to disperse, and the treatment cycle is repeated until the desired results are achieved. To assess the success of the procedure, intravascular ultrasound (IVUS) or optical coherence imaging may be employed post-procedure. In many cases, a stent may be placed across the lesion following the IVL treatment to further support the artery and maintain patency.
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