© Copyright 2026 American Medical Association. All rights reserved.
The endomyocardial biopsy, as described by CPT® Code 93505, is a medical procedure in which a physician obtains a small sample of heart tissue for diagnostic purposes. This procedure is essential for evaluating various cardiac conditions, particularly when there is a need to assess myocardial inflammation, infiltrative diseases, or to confirm a diagnosis of cardiomyopathy. The process begins with the preparation of the cannulation site, which involves cleansing the area and administering a local anesthetic to minimize discomfort for the patient. Depending on whether a right or left ventricular biopsy is being performed, the physician will select an appropriate access point; typically, the right internal jugular vein is used for right ventricular biopsies, while the right or left femoral artery is chosen for left ventricular biopsies. Once the access site is prepared, a small incision is made to facilitate the insertion of a needle into the selected vessel. A guidewire is then placed through the needle, allowing for the introduction of a self-sealing sheath, which is advanced through the blood vessel and positioned within the heart's ventricle. The bioptome, a specialized instrument designed for tissue sampling, is introduced through the sheath and directed toward the septum of the heart. The physician carefully maneuvers the bioptome to the targeted biopsy site, where a tissue sample is collected. After the biopsy is completed, both the bioptome and sheath are removed, and pressure is applied to the access site to prevent bleeding. Finally, the skin incision is closed, and a pressure dressing is applied to ensure proper healing and minimize the risk of complications.
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