Need help choosing the right code?
Ask CasePilot about procedures, modifiers, bundling, and coding guidance.
Try CasePilot© Copyright 2026 American Medical Association. All rights reserved.
Allergen immunotherapy, commonly referred to as allergy shots, is a medical treatment designed to alleviate symptoms associated with allergic reactions. This procedure is particularly effective for individuals suffering from seasonal allergies, such as those triggered by pollen from grasses, weeds, and trees, as well as indoor allergies caused by dust mites, pet dander, and molds. The process begins with allergy testing, which is a separate and reportable service, to identify the specific allergens that provoke the patient's symptoms. Once the allergens are identified, a tailored immunotherapy schedule is established, which consists of two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive small but progressively increasing doses of the allergenic extract(s) through injections, typically administered in the upper arm, on a frequency of one to three times per week. This phase generally lasts between three to six months. Following the build-up phase, patients transition to the maintenance phase, where they receive monthly injections for an extended period, usually ranging from three to five years. The allergenic extract used in this therapy is prepared and provided by the physician or another qualified healthcare professional. For billing purposes, CPT® Code 95120 is utilized for a single injection during an encounter, while CPT® Code 95125 is designated for encounters where two or more injections are administered.
© Copyright 2026 Coding Ahead. All rights reserved.
Allergen immunotherapy is indicated for patients experiencing allergic reactions due to specific allergens. The following conditions are commonly treated with this procedure:
The procedure for allergen immunotherapy involves several key steps that ensure the safe and effective administration of allergenic extracts. The following outlines the procedural steps:
After the administration of allergen immunotherapy, patients are typically monitored for any immediate adverse reactions, which may include localized swelling or redness at the injection site. It is important for patients to report any unusual symptoms to their healthcare provider. The expected recovery period is generally straightforward, as most patients can resume normal activities shortly after the injection. Ongoing follow-up appointments are essential to assess the effectiveness of the therapy and make any necessary adjustments to the treatment plan. Additionally, patients should be educated on the importance of adhering to the scheduled injections to achieve optimal results from the immunotherapy.
| Short Descr | IMMUNOTHERAPY ONE INJECTION | Medium Descr | PROF SVCS ALLG IMMNTX W/PRV ALLGIC XTRC 1 NJX | Long Descr | Professional services for allergen immunotherapy in the office or institution of the prescribing physician or other qualified health care professional, including provision of allergenic extract; single injection | Status Code | Not Valid for Medicare Purposes | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Non-Covered Service, not paid under OPPS | Type of Service (TOS) | 1 - Medical Care | Berenson-Eggers TOS (BETOS) | M5D - Specialist - other | MUE | 0 | CCS Clinical Classification | 228 - Prophylactic vaccinations and inoculations |
|
Date
|
Action
|
Notes
|
|---|---|---|
| 2013-01-01 | Changed | Description Changed |
| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
Get instant expert-level medical coding assistance.