© Copyright 2026 American Medical Association. All rights reserved.
Allergen immunotherapy is a medical treatment designed to alleviate allergic reactions caused by stinging insects, such as bees, wasps, hornets, and yellow jackets. This therapy is particularly beneficial for individuals who have experienced severe allergic reactions, including anaphylaxis, to these insect stings. The process begins with allergy testing, which is performed separately to identify the specific allergens responsible for the patient's reactions. Once the allergens are identified, a tailored immunotherapy schedule is established, consisting of two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive small, gradually increasing doses of the allergenic extract, typically administered via injection into the upper arm. This phase usually occurs one to three times a week and lasts for approximately 3 to 6 months. Following this, the maintenance phase commences, where patients receive monthly injections of the allergenic extract for a duration of 3 to 5 years. The allergenic extract used in this therapy is prepared and provided by the prescribing physician or another qualified healthcare professional. For billing purposes, CPT® Code 95130 is utilized for the injection of a single stinging insect venom extract, while additional codes are available for multiple venoms, allowing for accurate coding based on the number of allergens treated.
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