© Copyright 2026 American Medical Association. All rights reserved.
Allergen immunotherapy is a medical treatment designed to alleviate allergic reactions caused by stinging insects, including bees, wasps, hornets, and yellow jackets. This therapy involves a systematic approach to desensitize the patient's immune system to specific allergens identified through prior allergy testing. The treatment is structured into two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive progressively increasing doses of the allergenic extract, typically administered via injection into the upper arm. This phase generally spans a duration of 3 to 6 months, with injections occurring one to three times per week, depending on the individual's response and treatment plan. Following the build-up phase, patients transition to the maintenance phase, which consists of monthly injections that can last for a period of 3 to 5 years. The allergenic extract used in this therapy is prepared and provided by the prescribing physician or another qualified healthcare professional. For billing purposes, specific CPT® codes are designated for the administration of allergenic extracts based on the number of stinging insect venoms involved, with code 95133 specifically applicable for the administration of four stinging insect venoms.
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