© Copyright 2026 American Medical Association. All rights reserved.
Allergen immunotherapy is a medical treatment designed to alleviate allergic reactions caused by stinging insects, including bees, wasps, hornets, and yellow jackets. This therapy involves a systematic approach to desensitize the patient's immune response to specific insect venoms. Initially, a thorough allergy testing process is conducted to identify the exact stinging insect allergen(s) responsible for the patient's allergic reactions. Once identified, a tailored immunotherapy schedule is established, which consists of two distinct phases: the build-up phase and the maintenance phase. During the build-up phase, patients receive progressively increasing doses of the allergenic extract(s) through injections, typically administered in the upper arm, at intervals of one to three times per week. This phase generally spans a duration of 3 to 6 months. Following the build-up phase, patients transition to the maintenance phase, where they receive monthly injections for an extended period, usually lasting between 3 to 5 years. The allergenic extract utilized in this therapy is prepared and provided by the prescribing physician or another qualified healthcare professional. For billing purposes, specific CPT® codes are designated for the administration of allergenic extracts based on the number of stinging insect venoms involved, with code 95134 specifically applicable for the administration of five stinging insect venoms.
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