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Official Description

Testing of autonomic nervous system function; cardiovagal innervation (parasympathetic function), including 2 or more of the following: heart rate response to deep breathing with recorded R-R interval, Valsalva ratio, and 30:15 ratio

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 95921 pertains to the testing of autonomic nervous system function, specifically focusing on cardiovagal innervation, which is a component of the parasympathetic nervous system. The autonomic nervous system (ANS) is crucial for regulating involuntary bodily functions, and it is divided into two main branches: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system is primarily responsible for the body's 'fight or flight' responses, including the regulation of blood pressure, while the parasympathetic nervous system, which includes cardiovagal innervation, plays a vital role in controlling heart rate and promoting a state of rest and digest. In the context of CPT® Code 95921, the assessment involves evaluating the parasympathetic function through various tests that measure heart rate responses under different conditions. These tests include the heart rate response to deep breathing, the Valsalva maneuver, and the calculation of the 30:15 ratio, which assesses the heart rate variability when transitioning from a lying to a standing position. An electrocardiographic (ECG) rhythm strip is utilized to record the heart rate and the R-R intervals, which are the times between successive heartbeats. The results of these tests provide valuable insights into the functioning of the autonomic nervous system, particularly the parasympathetic component, and help in diagnosing potential autonomic dysfunctions. The physician conducting the tests will review the data collected and generate a comprehensive written report detailing the findings of the autonomic function tests.

© Copyright 2026 Coding Ahead. All rights reserved.

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