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Official Description

Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

CPT® Code 96401 refers to the administration of chemotherapy through subcutaneous or intramuscular routes specifically for non-hormonal anti-neoplastic agents. This procedure involves the careful injection of medication into the body to treat cancer by targeting and inhibiting the growth of malignant cells. The subcutaneous injection is performed by inserting a needle just beneath the skin into the fatty tissue, typically located in areas such as the abdomen, upper arm, upper leg, or buttocks. The process begins with cleansing the skin to prevent infection, followed by pinching a fold of skin to create a stable injection site. The needle is then inserted at an angle between 45 to 90 degrees, depending on the specific technique used. In contrast, the intramuscular injection is delivered deeper into the muscle tissue, which allows for quicker absorption of the medication into the bloodstream. Common sites for intramuscular injections include the gluteal muscles of the buttocks, the vastus lateralis muscle of the thigh, and the deltoid muscle of the upper arm, with the needle inserted at a 90-degree angle. This method is particularly beneficial for administering larger doses of chemotherapy agents, ensuring rapid systemic absorption. It is important to note that CPT® Code 96401 is designated for non-hormonal anti-neoplastic agents, while a different code, CPT® Code 96402, is used for hormonal anti-neoplastic agents.

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