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Official Description

Chemotherapy administration, intravenous infusion technique; initiation of prolonged chemotherapy infusion (more than 8 hours), requiring use of a portable or implantable pump

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 96416 refers to the administration of chemotherapy through an intravenous infusion technique, specifically for the initiation of a prolonged chemotherapy infusion that lasts more than eight hours. This procedure necessitates the use of a portable or implantable pump to deliver the chemotherapy agent effectively. In this context, chemotherapy is a treatment method that utilizes specific drugs to target and destroy malignant neoplasms, which are cancerous tumors. The administration process involves placing an intravenous line into a vein, typically located in the patient's arm, through which the chemotherapy substance is infused. During this procedure, the physician plays a critical role by providing direct supervision, ensuring that they are immediately available to address any complications that may arise during the infusion. Additionally, the physician is responsible for conducting periodic assessments of the patient's condition and documenting their response to the treatment, which is essential for monitoring the effectiveness of the chemotherapy and making any necessary adjustments to the treatment plan. For shorter infusions, such as those lasting up to one hour, the appropriate code is 96413, while for each additional hour of infusion, the add-on code 96415 should be used. In cases where an additional sequential infusion of a different chemotherapy substance or drug is required for up to one hour, the add-on code 96417 is applicable.

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