CPT® Code 96450

CPT® Code 96450 refers to the administration of chemotherapy directly into the central nervous system (CNS), specifically through a method known as intrathecal chemotherapy. This procedure involves the injection of one or more antineoplastic drugs into the cerebrospinal fluid (CSF) that surrounds the spinal cord and brain. The process begins with the disinfection of the skin over the lumbar spine, followed by the administration of a local anesthetic to minimize discomfort during the procedure. A lumbar puncture needle is then carefully inserted into the spinal canal to access the CSF. During this procedure, CSF specimens may be collected for diagnostic purposes if necessary. Subsequently, a spinal catheter is advanced through the lumbar puncture needle, allowing for the direct injection of the antineoplastic drugs into the spinal fluid. This method ensures that the drugs are effectively delivered to the CNS, where they can exert their therapeutic effects against cancerous cells. After the injection, the spinal catheter is removed, and pressure is applied to the puncture site to prevent any complications. This procedure is critical for treating certain types of cancers that affect the CNS, as it allows for higher concentrations of chemotherapy to be delivered directly to the site of action while minimizing systemic exposure.