© Copyright 2026 American Medical Association. All rights reserved.
Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a specialized procedure that involves the administration of heated chemotherapy directly into the peritoneal cavity during surgery. This technique is primarily utilized after the surgical excision of malignant tumors located in the abdominal region. The objective of HIPEC is to eliminate any residual cancer cells that may remain after the tumor has been removed, thereby reducing the risk of recurrence. The chemotherapy agents used in this procedure are heated to temperatures between 41-43 degrees Celsius (106-109 degrees Fahrenheit), which enhances their effectiveness by allowing deeper penetration into the cancerous tissues. The procedure is characterized by the use of separate incisions for the insertion of catheters that facilitate the delivery and circulation of the heated chemotherapy solution throughout the abdominal cavity. This localized treatment approach minimizes systemic exposure to the chemotherapy drugs, thereby reducing potential side effects associated with traditional chemotherapy methods. The entire process typically lasts for about 60 minutes, during which the heated solution is circulated, and upon completion, it is drained from the abdomen, followed by rinsing with saline and closure of the incisions.
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