© Copyright 2026 American Medical Association. All rights reserved.
Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a specialized procedure designed to deliver heated chemotherapy directly into the abdominal cavity during surgery. This technique is primarily utilized after the surgical removal of cancerous tumors from the abdomen, with the goal of targeting any residual cancer cells that may remain. The procedure involves the application of heated chemotherapy agents, which are circulated through the peritoneal cavity, allowing for a concentrated and localized treatment. The heating of the chemotherapy drugs enhances their effectiveness by increasing their penetration into the cancer cells and improving their cytotoxic effects. This method minimizes systemic exposure, as the chemotherapy is confined to the abdominal area, reducing potential side effects associated with traditional chemotherapy administration. The procedure may necessitate the creation of additional small incisions, particularly when performed using minimally invasive techniques, to facilitate the placement of catheters that connect to a perfusion machine. This machine is responsible for heating the chemotherapy solution to temperatures between 41-43 degrees Celsius (106-109 degrees Fahrenheit) before it is infused into the abdominal cavity. The infusion typically lasts for one to two hours, after which the solution is drained, and the abdomen is rinsed with saline before closing the incisions. This targeted approach aims to improve treatment outcomes for patients with abdominal cancers by effectively addressing localized disease while minimizing the impact on the rest of the body.
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