© Copyright 2026 American Medical Association. All rights reserved.
Reflectance confocal microscopy (RCM) is a sophisticated, non-invasive imaging technique utilized for the detailed examination of skin cell populations. This procedure is particularly valuable in the assessment of both benign and malignant tumors, specifically those involving melanocytes and keratinocytes. During the RCM process, a diode laser emits near-infrared light that is precisely focused on a targeted area of the skin. As this light penetrates the cellular structures, it interacts with them, resulting in variations in the refraction indexes and natural light reflections. These interactions are captured and processed using advanced computer software, which reconstructs the data into a two-dimensional grayscale image. The high-resolution images generated through this method allow for a comprehensive histological analysis of the lesion, enabling healthcare professionals to make informed decisions regarding diagnosis and treatment. The CPT® Code 96931 specifically encompasses the complete process of reflectance confocal microscopy for the first lesion, including the image acquisition, interpretation, and the generation of a report. For additional lesions, separate codes such as 96934, 96932, 96933, and 96935 are designated to account for the varying components of the procedure performed on subsequent lesions.
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