CPT® Code 25066

The procedure described by CPT® Code 25066 refers to a biopsy of the soft tissue located in the forearm and/or wrist, specifically targeting deeper structures such as those beneath the fascia or within the muscle itself. A soft tissue biopsy is a surgical procedure that involves the removal of a small sample of tissue for diagnostic purposes. The term "soft tissue" encompasses various types of biological materials, including muscles, tendons, fat, blood vessels, lymph vessels, nerves, and the connective tissues surrounding joints. This procedure is typically performed when there is a need to investigate abnormalities or lesions that may not be accessible through superficial methods. Prior to the biopsy, anesthesia—whether local, regional, or general—is administered to ensure patient comfort during the procedure. The area of the skin over the biopsy site is meticulously cleansed to minimize the risk of infection. An incision is then made, allowing the surgeon to carefully dissect through the layers of tissue down to the targeted mass or lesion, while taking precautions to avoid damaging any nearby blood vessels or nerves. Once the tissue sample is obtained, it is sent to a laboratory for histological evaluation, which is reported separately. After the sample is collected, the incision is closed using sutures to promote proper healing. It is important to note that CPT® Code 25066 is specifically designated for deeper biopsies that require more extensive dissection compared to superficial biopsies, which are coded under CPT® Code 25065.