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Official Description

Destruction by neurolytic agent, trigeminal nerve; second and third division branches at foramen ovale under radiologic monitoring

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 64610 involves the destruction of the trigeminal nerve's second and third division branches at the foramen ovale using a neurolytic agent, specifically under radiologic monitoring. This intervention is primarily aimed at alleviating chronic pain, particularly in patients suffering from conditions such as trigeminal neuralgia. The destruction of nerve tissue can be achieved through various techniques, including the injection of a chemical neurolytic agent or the application of thermal, electrical, or radiofrequency methods. Among these, radiofrequency destruction is the most commonly utilized technique in contemporary practice. The procedure begins with the introduction of an electrode needle through the skin, which is then carefully advanced toward the targeted neural tissue. This needle is connected to a generator that facilitates motor and sensory testing, ensuring accurate positioning at the nerve responsible for the patient's pain. Once the correct nerve pathway is identified, the destruction process is initiated. If a chemical neurolytic agent is employed, it is injected along the nerve pathway to achieve the desired effect. Common neurolytic agents include phenol, ethyl alcohol, glycerol, ammonium salt compounds, and hypertonic or hypotonic solutions. Alternatively, thermal or electrical modalities may be used, where a probe or needle is inserted through the skin and activated to generate heat, effectively destroying the nerve tissue. In the case of radiofrequency nerve destruction, the electrode needle is positioned accurately, and the radiofrequency device is activated to produce heat at the electrode's tip, leading to the destruction of the targeted nerve tissue. It is important to note that for procedures involving the destruction of other branches of the trigeminal nerve, such as the supraorbital, infraorbital, mental, or inferior alveolar branches, different CPT codes are applicable, specifically CPT® Code 64600. Additionally, for the second or third division branches of the trigeminal nerve at the foramen ovale, CPT® Code 64605 is used when the procedure is performed without radiologic monitoring, while CPT® Code 64610 is designated for procedures conducted with radiologic oversight.

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