© Copyright 2026 American Medical Association. All rights reserved.
The procedure described by CPT® Code 65778 involves the placement of an amniotic membrane on the ocular surface without the use of sutures. This technique utilizes a dried amniotic membrane, which is harvested from placental tissue, to promote healing in the eye. The amniotic membrane is known for its beneficial properties in wound healing due to its anti-inflammatory and anti-scarring effects. Prior to the application of the membrane, the eye is prepared by irrigating it with normal saline, and antibiotic drops may be administered as needed for a duration of 24 to 48 hours. Anesthetic eye drops or a facial nerve block is utilized to ensure the patient experiences minimal discomfort during the procedure. To facilitate the application of the amniotic membrane, an eye speculum is employed to keep the eye open. The procedure involves obtaining a piece of amniotic membrane from a tissue bank, which is cut to a size that matches the conjunctival sac. A circular opening is created in the membrane to prevent coverage of the entire cornea, as doing so could lead to temporary hazy vision. The amniotic membrane is then carefully spread over the wound and the healthy conjunctiva, starting from the upper fornix while the patient looks down, and then over the lower fornix as the patient looks up. After the membrane is positioned, the eye speculum is removed, and liquid paraffin is applied to seal the eye closed. Both eyes are subsequently bandaged for a period of 24 to 48 hours to allow for the absorption of the amniotic membrane, facilitating the healing process without the need for sutures.
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