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Official Description

Procainamide; with metabolites (eg, n-acetyl procainamide)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Procainamide is a medication classified as a cardiac antidysrhythmic agent, primarily utilized to manage and treat abnormal heart rhythms, particularly ventricular tachycardia. The CPT® Code 80192 specifically refers to a laboratory test that quantifies the levels of procainamide in the blood, along with its metabolites, notably n-acetyl procainamide. This test is crucial for monitoring the concentration of the drug in the bloodstream to ensure that therapeutic levels are maintained, thereby optimizing treatment efficacy and minimizing potential toxicity. The measurement of procainamide and its metabolites is essential, as it helps healthcare providers assess the patient's response to the medication and make necessary adjustments to the dosage. The test is performed on a blood sample obtained through venipuncture, which is a standard procedure for collecting blood for laboratory analysis. The analysis is conducted using a fluorescence polarization immunoassay, a sensitive and specific method that allows for accurate detection of drug levels. Monitoring procainamide levels is particularly important due to the risk of adverse effects, including the formation of antinuclear antibodies, which can lead to symptoms resembling systemic lupus erythematosus. Regular testing ensures that patients receive the appropriate therapeutic benefits while minimizing the risk of complications associated with improper dosing.

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