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Code deleted. See 80305, 80306, 80307.

Official Description

Drug screen, presumptive, single drug class from Drug Class List B, by immunoassay (eg, ELISA) or non-TLC chromatography without mass spectrometry (eg, GC, HPLC), each procedure

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80302 refers to a presumptive drug screening procedure that identifies a single drug class from Drug Class List B. This laboratory test is primarily conducted on urine samples, although it can also be performed on other biological specimens such as blood, saliva, hair, and sweat. Drug Class List B encompasses a variety of substances, including acetaminophen, carisoprodol/meprobamate, ethyl glucuronide, fentanyl, ketamine, meperidine, methylphenidate, nicotine/cotinine, salicylate, synthetic cannabinoids, tapentadol, tramadol, zolpidem, and drugs not otherwise specified. The testing methods employed for this procedure include enzyme-linked immunosorbent assay (ELISA), gas chromatography (GC), and high-performance liquid chromatography (HPLC). ELISA is a rapid and precise method that utilizes antibody-antigen interactions to detect specific analytes, while GC and HPLC are chromatographic techniques that separate and identify compounds in a sample based on their chemical properties. These methodologies ensure accurate detection of the specified drug class, aiding in clinical decision-making and patient management.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 80302 is indicated for use in various clinical scenarios where the identification of a specific drug class from Drug Class List B is necessary. This may include situations such as:

  • Substance Abuse Evaluation to assess potential drug use in patients.
  • Monitoring Treatment Compliance in patients undergoing therapy for substance use disorders.
  • Pre-employment Screening to ensure candidates are not using prohibited substances.
  • Post-Accident Testing to determine if drug use contributed to an incident.
  • Clinical Assessment in cases of suspected overdose or adverse drug reactions.

2. Procedure

The procedure for CPT® Code 80302 involves several key steps to ensure accurate drug screening. These steps include:

  • Sample Collection involves obtaining a urine sample, although other biological specimens such as blood, saliva, hair, or sweat may also be used. Proper collection techniques must be followed to avoid contamination and ensure the integrity of the sample.
  • Sample Preparation requires the laboratory to prepare the sample for analysis. This may involve dilution or other preparatory steps to ensure that the sample is suitable for the chosen testing method.
  • Testing Method Selection involves choosing the appropriate analytical technique, such as ELISA, GC, or HPLC, based on the specific requirements of the test and the substances being screened.
  • Analysis is conducted using the selected method. For ELISA, the sample is mixed with antibodies that bind to the target analytes, producing a measurable signal. In GC, the sample is vaporized and passed through a column to separate the components, while HPLC uses solvents to move analytes through a column for separation and identification.
  • Result Interpretation involves analyzing the data obtained from the testing method to determine the presence or absence of the specified drug class. Results are then documented and reported to the requesting physician or healthcare provider.

3. Post-Procedure

After the completion of the drug screening procedure under CPT® Code 80302, the laboratory will provide a report detailing the findings. It is essential for healthcare providers to review the results in conjunction with the patient's clinical history and other relevant information. Follow-up actions may include further confirmatory testing if the presumptive test indicates a positive result, as well as discussions with the patient regarding the implications of the findings. Additionally, proper documentation of the procedure and results is crucial for compliance and billing purposes.

Short Descr DRUG SCREEN PRSMPTV 1 CLASS
Medium Descr DRUG SCREEN PRESUMPTIVE 1 CLASS METHOD LIST B
Long Descr Drug screen, presumptive, single drug class from Drug Class List B, by immunoassay (eg, ELISA) or non-TLC chromatography without mass spectrometry (eg, GC, HPLC), each procedure
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x)
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE Not applicable/unspecified.
Date
Action
Notes
2016-12-31 Deleted Code deleted. See 80305, 80306, 80307.
2015-01-01 Added Added
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