CPT® Code 81535

Oncology (gynecologic), live tumor cell culture and chemotherapeutic response by DAPI stain and morphology, predictive algorithm reported as a drug response score; first single drug or drug combination

The CPT® Code 81535 pertains to a specialized laboratory test utilized in the field of oncology, specifically focusing on gynecologic tumors. This procedure involves the culture of live tumor cells obtained from a gynecologic tumor, which are then subjected to a series of tests to evaluate their response to various chemotherapeutic agents. The primary objective of this test is to determine how effectively these drugs can target and kill the tumor cells, thereby aiding in the selection of the most appropriate chemotherapy regimen for the patient. The test employs DAPI (4’, 6-diamidino-2-phenylindole) stain, a fluorescent dye that binds to DNA, allowing for the differentiation between live and dead cells. This is crucial as it provides insight into the viability of the tumor cells after exposure to the chemotherapeutic agents. The results are quantified and reported as a drug response score, which is derived from a predictive algorithm that assesses the cells' morphological characteristics and their reaction to the drugs tested. This code specifically covers the first single drug or drug combination tested, while additional drugs or combinations can be reported using CPT® Code 81536. Overall, this procedure is instrumental in personalizing cancer treatment, ensuring that patients receive the most effective therapies based on the unique characteristics of their tumors.