CPT® Code 81536

Add-On Code

Oncology (gynecologic), live tumor cell culture and chemotherapeutic response by DAPI stain and morphology, predictive algorithm reported as a drug response score; each additional single drug or drug combination (List separately in addition to code for primary procedure)

The CPT® Code 81536 pertains to a specialized laboratory test utilized in the field of oncology, specifically focusing on gynecologic tumors. This procedure involves the culture of live tumor cells, which are obtained from a gynecologic tumor specimen. The primary objective of this test is to evaluate the response of these tumor cells to various chemotherapeutic agents. The assessment is conducted using a technique that incorporates DAPI (4’, 6-diamidino-2-phenylindole) staining and morphological analysis. DAPI is a fluorescent stain that selectively binds to A-T-rich regions of DNA, allowing for a clear distinction between live and dead cells. This characteristic is crucial, as it enables the laboratory to determine the viability of the tumor cells after exposure to chemotherapeutic drugs. The test is designed to identify the most effective chemotherapeutic regimens tailored to the unique characteristics of the tumor, thereby enhancing treatment precision. The results are reported as a drug response score, which is derived from a predictive algorithm that analyzes the survival rates of the tumor cells in response to the administered drugs. It is important to note that CPT® Code 81536 is used in conjunction with CPT® Code 81535, which covers the first single drug or drug combination tested. Code 81536 serves as an adjunct code for each additional single drug or drug combination evaluated, thereby facilitating a comprehensive assessment of the tumor's response to multiple therapeutic options.