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Official Description

Acylcarnitines; qualitative, each specimen

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82016 refers to a qualitative test for acylcarnitines, which are compounds involved in the metabolism of fatty acids. This blood test is designed to identify the presence or absence of acylcarnitines in the blood, providing crucial information for diagnosing certain metabolic disorders. The test is particularly significant in newborn screening programs, where it is routinely performed on infants to detect conditions related to fatty acid beta-oxidation and organic aciduria disorders. However, it is not limited to infants; the test may also be conducted at any age if symptoms indicative of these metabolic disorders are present. To perform the test, a blood sample is collected, which can be obtained through a venipuncture or a capillary draw, both of which are separately reportable procedures. The analysis of the blood sample is conducted using low injection analysis-tandem mass spectrometry, a sophisticated technique that allows for precise identification of acylcarnitines. Each specimen obtained for this test must be reported using the CPT® Code 82016, ensuring accurate tracking and billing for the procedure.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The qualitative acylcarnitine test (CPT® Code 82016) is indicated for the following conditions:

  • Newborn Screening This test is routinely performed on infants as part of newborn screening programs to identify metabolic disorders related to fatty acid beta-oxidation and organic aciduria.
  • Symptoms of Metabolic Disorders The test may also be conducted at any age when symptoms suggestive of fatty acid metabolism disorders are present.

2. Procedure

The procedure for conducting the qualitative acylcarnitine test involves several key steps:

  • Step 1: Sample Collection A blood sample is obtained from the patient, which can be done through a venipuncture or a capillary draw. It is important to note that both methods of blood collection are separately reportable, ensuring that the procedure is accurately documented for billing purposes.
  • Step 2: Sample Preparation Once the blood sample is collected, it is processed to separate the plasma or whole blood, which is necessary for the subsequent analysis. This step is crucial as it prepares the sample for testing, ensuring that the results will be accurate and reliable.
  • Step 3: Testing Methodology The prepared plasma or whole blood is then analyzed using low injection analysis-tandem mass spectrometry. This advanced analytical technique allows for the precise identification and qualitative assessment of acylcarnitines present in the blood sample.
  • Step 4: Reporting After the analysis is complete, the results are documented, and the CPT® Code 82016 is reported for each separate specimen obtained. This ensures proper tracking and billing for the test performed.

3. Post-Procedure

Post-procedure care for patients undergoing the qualitative acylcarnitine test is generally minimal, as the test is non-invasive and does not require extensive recovery time. Patients may resume normal activities immediately following the blood draw. However, it is essential to monitor for any potential complications related to the venipuncture or capillary draw, such as bruising or discomfort at the site of the blood collection. The results of the test will be communicated to the healthcare provider, who will interpret the findings in the context of the patient's clinical presentation and determine if further testing or intervention is necessary.

Short Descr ACYLCARNITINES QUAL
Medium Descr ACYLCARNITINES QUALITATIVE EACH SPECIMEN
Long Descr Acylcarnitines; qualitative, each specimen
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
Code
Description
Code
Description
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