CPT® Code 82653

The CPT® Code 82653 refers to a laboratory test that quantitatively measures the level of pancreatic elastase (EL-1) in fecal samples. Pancreatic elastase is a glycoprotein digestive enzyme produced by the acinar cells of the pancreas. Its primary function is to aid in the digestion of food by breaking down proteins, which facilitates the absorption of essential nutrients in the intestine. Additionally, pancreatic elastase plays a role in the transport of cholesterol by combining with bile acids and neutral steroids. The fecal test for EL-1 is particularly useful in assessing pancreatic function, especially in patients diagnosed with cystic fibrosis. This test can also help in diagnosing or ruling out conditions associated with pancreatic exocrine insufficiency, such as chronic pancreatitis, pancreatic tumors, cholelithiasis, and diabetes mellitus. Prior to conducting the test, it is essential to discontinue any pancreatic enzyme supplements to ensure accurate results. A sample of formed stool is collected in a clean container, and the analysis is performed using the enzyme-linked immunosorbent assay (ELISA) method. For a quantitative assessment of pancreatic elastase levels, the appropriate code to report is 82653, while 82656 should be used for qualitative or semi-quantitative tests that only determine the presence of EL-1.