CPT® Code 82656

The CPT® Code 82656 refers to a laboratory test that assesses the presence of pancreatic elastase (EL-1) in fecal samples, providing either a qualitative or semi-quantitative result. Pancreatic elastase is a glycoprotein digestive enzyme produced by the acinar cells of the pancreas. Once synthesized, it is released into the intestine, where it plays a crucial role in the digestion of food, aiding in the absorption of nutrients. Additionally, pancreatic elastase interacts with bile acids and neutral steroids to facilitate the transport of cholesterol within the body. The fecal test for EL-1 is particularly valuable in monitoring pancreatic function, especially in patients diagnosed with cystic fibrosis. Furthermore, this test can assist healthcare providers in diagnosing or ruling out conditions associated with pancreatic exocrine insufficiency, which may arise from chronic pancreatitis, cystic fibrosis, pancreatic tumors, cholelithiasis, or diabetes mellitus. It is important to note that prior to conducting this test, any pancreatic enzyme supplements should be discontinued to ensure accurate results. The test involves collecting a sample of formed stool in a clean container, which is then analyzed using the enzyme-linked immunosorbent assay (ELISA) method. For quantitative measurements of pancreatic elastase, the CPT® Code 82653 should be reported, while CPT® Code 82656 is designated for qualitative or semi-quantitative assessments of EL-1 presence.