CPT® Code 83013

The CPT® Code 83013 refers to a laboratory test specifically designed to analyze breath samples for urease activity, utilizing a non-radioactive isotope, such as Carbon-13 (C-13). This test is primarily employed in the diagnosis and monitoring of Helicobacter pylori (H. pylori) infections, which are associated with various gastrointestinal conditions, including chronic active gastritis, duodenal ulcers, and nonulcerative dyspepsia. H. pylori is a type of bacterium that resides in the stomach, where it burrows into the gastric mucosa to access the less acidic epithelial cells. To survive in the harsh acidic environment of the stomach, H. pylori produces an enzyme known as urease. This enzyme plays a crucial role in the bacterium's ability to thrive, as it catalyzes the conversion of urea into ammonia and carbon dioxide, leading to inflammation and an immune response in the gastric lining. The testing process begins with the collection of a baseline breath sample from the patient. Following this, the patient ingests a capsule or solution containing 75 mg of reconstituted Pranactin-Citric, which includes (13) C-urea. Once ingested, the (13) C-urea is broken down in the stomach, producing (13) CO2 and ammonia. A second breath sample is collected approximately 13 to 18 minutes after ingestion. If H. pylori is present in the stomach, the urease produced by the bacteria will facilitate the conversion of (13) C-urea into (13) CO2, which is then absorbed into the bloodstream and subsequently exhaled. The analysis of the exhaled breath is conducted using quantitative infrared spectrophotometry, a method that allows for precise measurement of the (13) CO2 levels. The CPT® Code 83013 encompasses the analysis of the breath sample and includes the costs associated with the medication and test supplies necessary for the procedure.