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Official Description

Lipoprotein, direct measurement; high density cholesterol (HDL cholesterol)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83718 refers to a specific laboratory test that measures high-density lipoprotein (HDL) cholesterol levels in the blood. HDL cholesterol is a type of lipoprotein that plays a crucial role in the body's lipid metabolism. Lipoproteins are complex particles composed of lipids, such as cholesterol and triglycerides, bound to proteins. They are essential for transporting fats through the bloodstream. The size and density of lipoproteins can vary significantly; they can be classified as large and less dense, which contain more fat than protein, or small and more dense, which contain more protein than fat. Lipoproteins can originate from dietary sources, known as exogenous lipoproteins, or can be produced by the liver, referred to as endogenous lipoproteins. Among the various types of lipoproteins, low-density lipoproteins (LDL) are particularly noteworthy due to their association with cardiovascular disease (CVD). LDL particles can vary in size and density, with small dense LDL (sdLDL) being particularly harmful as it is more likely to contribute to atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. In contrast, HDL cholesterol is often termed "good" cholesterol because it helps to remove excess cholesterol from the bloodstream, thereby reducing the risk of atherosclerosis and CVD. The direct measurement of HDL cholesterol, as indicated by CPT® Code 83718, is performed using a specific laboratory test that employs detergent solubilization and enzymatic methodologies. This method provides a more accurate assessment of HDL levels compared to calculations based on total cholesterol, HDL, and triglycerides. A blood sample for this test is obtained through venipuncture, which is a separate and reportable procedure. Understanding HDL cholesterol levels is vital for evaluating cardiovascular health and guiding treatment decisions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 83718 is indicated for the assessment of high-density lipoprotein (HDL) cholesterol levels in patients. This test is typically performed in the following scenarios:

  • Cardiovascular Risk Assessment The measurement of HDL cholesterol is crucial for evaluating a patient's risk of developing cardiovascular diseases (CVD), including heart attacks and strokes.
  • Monitoring Lipid Disorders Patients with known lipid disorders may require regular monitoring of their HDL levels to assess the effectiveness of treatment interventions.
  • Evaluating Metabolic Syndrome Individuals suspected of having metabolic syndrome, which is characterized by a cluster of conditions that increase the risk of heart disease and diabetes, may undergo this test to evaluate their lipid profile.

2. Procedure

The procedure for CPT® Code 83718 involves several key steps to ensure accurate measurement of HDL cholesterol levels:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to fast for a specific period, typically 9 to 12 hours, to ensure accurate lipid measurements. This fasting period helps to minimize the influence of recent food intake on lipid levels.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves inserting a needle into a vein, usually in the arm, to collect the necessary serum or plasma for testing. The procedure is typically quick and may involve the use of a tourniquet to facilitate blood flow.
  • Step 3: Laboratory Analysis The collected blood sample is sent to a laboratory where it undergoes analysis. The HDL cholesterol levels are measured using a specific methodology that involves detergent solubilization and enzymatic reactions. This direct measurement provides a precise quantification of HDL cholesterol in the serum or plasma.
  • Step 4: Result Interpretation Once the analysis is complete, the laboratory generates a report detailing the HDL cholesterol levels. These results are then interpreted by the healthcare provider in the context of the patient's overall lipid profile and cardiovascular risk factors.

3. Post-Procedure

After the procedure associated with CPT® Code 83718, patients may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, but patients are generally advised to resume normal activities immediately. The healthcare provider will review the HDL cholesterol results with the patient during a follow-up appointment, discussing any necessary lifestyle changes or treatment options based on the findings. Regular monitoring of HDL levels may be recommended as part of an ongoing strategy to manage cardiovascular health.

Short Descr ASSAY OF LIPOPROTEIN
Medium Descr LIPOPROTEIN DIR MEAS HIGH DENSITY CHOLESTEROL
Long Descr Lipoprotein, direct measurement; high density cholesterol (HDL cholesterol)
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) Yes
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
QW Clia waived test
GA Waiver of liability statement issued as required by payer policy, individual case
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q4 Service for ordering/referring physician qualifies as a service exemption
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
AY Item or service furnished to an esrd patient that is not for the treatment of esrd
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GX Notice of liability issued, voluntary under payer policy
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QP Documentation is on file showing that the laboratory test(s) was ordered individually or ordered as a cpt-recognized panel other than automated profile codes 80002-80019, g0058, g0059, and g0060.
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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