CPT® Code 83901

Deleted

Molecular diagnostics; amplification, target, multiplex, each additional nucleic acid sequence beyond 2 (List separately in addition to code for primary procedure)

A molecular diagnostics test is a specialized laboratory procedure that utilizes target amplification techniques to replicate specific nucleic acid sequences, such as DNA or RNA. This process is essential for identifying particular genes and proteins, as well as understanding their interactions within cells. Molecular diagnostics focuses on analyzing patterns of gene and protein activity, which can reveal significant changes indicative of various diseases, including cancer, infections, and genetic disorders that may be inherited or acquired. The field of molecular diagnostics is rapidly evolving, with new applications emerging regularly, enhancing its role in modern medicine.

To perform this test, a biological sample—such as blood, urine, sputum, or tissue—is collected from the patient. The nucleic acid intended for amplification is then prepared and isolated through a separate, reportable procedure. Following this preparation, target amplification is conducted, which involves generating multiple copies of the specific nucleic acid sequence. This amplification process can be repeated, allowing for further replication of each copy. In cases where target amplification is necessary for more than one nucleic acid sequence, each sequence is reported separately. The initial two nucleic acid sequences are reported using CPT® code 83900, which employs multiplex technology to amplify multiple sequences simultaneously, potentially targeting 100 or more sequences at once. For each additional nucleic acid sequence beyond the first two, CPT® code 83901 is utilized, ensuring accurate reporting and billing for the comprehensive molecular diagnostic testing performed.