CPT® Code 84152

Prostate specific antigen (PSA) is a protein that is produced by normal prostate cells and is found in the serum. It exists in two forms: free PSA and complexed PSA, the latter being bound to other proteins. The measurement of complexed PSA, as indicated by CPT® Code 84152, involves a direct measurement technique that quantifies the amount of PSA that is complexed with other proteins in the blood. Elevated levels of complexed PSA can be indicative of prostate cancer and are considered to be a more reliable marker for malignancy compared to total PSA levels. Total PSA, which encompasses both free and complexed forms, is measured under CPT® Code 84153 and is often utilized for screening purposes and monitoring treatment responses in patients diagnosed with prostate cancer. However, total PSA alone is not sufficient for a definitive diagnosis of prostate cancer. Additionally, free PSA, measured under CPT® Code 84154, is frequently assessed alongside total PSA to provide further insights into the levels of complexed PSA, thereby aiding in the evaluation of prostate health and potential malignancy.