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Prostate specific antigen (PSA) is a protein that is produced by normal prostate cells and is found in the serum. It exists in two forms: free PSA and complexed PSA, the latter being bound to other proteins. The measurement of complexed PSA, as indicated by CPT® Code 84152, involves a direct measurement technique that quantifies the amount of PSA that is complexed with other proteins in the blood. Elevated levels of complexed PSA can be indicative of prostate cancer and are considered to be a more reliable marker for malignancy compared to total PSA levels. Total PSA, which encompasses both free and complexed forms, is measured under CPT® Code 84153 and is often utilized for screening purposes and monitoring treatment responses in patients diagnosed with prostate cancer. However, total PSA alone is not sufficient for a definitive diagnosis of prostate cancer. Additionally, free PSA, measured under CPT® Code 84154, is frequently assessed alongside total PSA to provide further insights into the levels of complexed PSA, thereby aiding in the evaluation of prostate health and potential malignancy.
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The measurement of complexed prostate specific antigen (PSA) is indicated for the following conditions:
The procedure for measuring complexed PSA involves several key steps:
After the procedure, patients may experience minimal discomfort at the site of blood draw, but no specific post-procedure care is typically required. The healthcare provider will discuss the results with the patient, including any necessary follow-up actions based on the complexed PSA levels. It is important for patients to understand that elevated complexed PSA levels may warrant further diagnostic evaluations or monitoring, depending on their individual clinical context.
| Short Descr | ASSAY OF PSA COMPLEXED | Medium Descr | ASSAY OF PROSTATE SPECIFIC ANTIGEN COMPLEXED | Long Descr | Prostate specific antigen (PSA); complexed (direct measurement) | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | GA | Waiver of liability statement issued as required by payer policy, individual case | GW | Service not related to the hospice patient's terminal condition | GZ | Item or service expected to be denied as not reasonable and necessary |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| 2011-01-01 | Changed | Short description changed. |
| 2001-01-01 | Added | First appearance in code book in 2001. |
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