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Official Description

Protein, total, except by refractometry; other source (eg, synovial fluid, cerebrospinal fluid)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 84157 refers to a laboratory test that measures the total protein concentration in body fluids other than blood or urine, specifically targeting fluids such as cerebrospinal fluid (CSF) and synovial fluid. This test is crucial for diagnosing various medical conditions, as it provides insights into the protein levels present in these fluids. Elevated protein levels in CSF can indicate serious conditions such as tumors, bleeding, inflammation, or injury affecting the brain or central nervous system. Conversely, a decrease in protein levels may suggest a rapid turnover or replacement of CSF, which can occur in certain medical scenarios. In the case of synovial fluid, an increase in total protein levels is typically associated with inflammatory processes. The collection of CSF is performed through a procedure known as a lumbar puncture, commonly referred to as a spinal tap, while synovial fluid is obtained via arthrocentesis, a procedure that involves the aspiration of fluid from the affected joint. The analysis of these body fluids is conducted using reflectance spectrophotometry, a method that allows for accurate measurement of protein concentrations.

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