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The CPT® Code 84376 refers to a laboratory test that is specifically designed to measure the presence of sugars, including mono-, di-, and oligosaccharides, in various specimens such as blood, body fluids, or excrement. Sugars are categorized based on their molecular structure: monosaccharides are single carbohydrate units, such as glucose, fructose, or galactose; disaccharides consist of two monosaccharides, examples being sucrose (composed of fructose and glucose), lactose (composed of glucose and galactose), and maltose (composed of two glucose units). The human body metabolizes these simple sugars to generate energy. Oligosaccharides, which are chains of 3 to 10 monosaccharides, can attach to proteins and lipids, forming complex structures known as glycans. These oligosaccharides are naturally found in plant fibers, such as starch and cellulose, and play a significant role as prebiotics, promoting the growth of beneficial bacteria in the large intestine, which in turn aids in the production of short-chain fatty acids (SCFAs) and certain B vitamins. The test associated with CPT® Code 84376 is particularly useful for screening carbohydrate malabsorption disorders and identifying lysosomal storage diseases, including mannosidosis, fucosidosis, GM1 gangliosidosis, and sialic acid storage disease. This code is utilized for the qualitative analysis of a single sugar substance and is applicable in scenarios where reducing substances are tested in fecal samples using colorimetric methods. For testing multiple sugar molecules, CPT® Code 84377 is employed, which may involve analyzing oligosaccharides in urine through thin layer chromatography.
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The CPT® Code 84376 is indicated for use in various clinical scenarios where the measurement of sugars is necessary. The following conditions and symptoms may warrant this laboratory test:
The procedure for conducting the test associated with CPT® Code 84376 involves several key steps to ensure accurate measurement of sugars in the specimen. The following procedural steps are typically followed:
After the procedure associated with CPT® Code 84376, the following post-procedure considerations are important. Patients may be advised on any necessary follow-up actions based on the test results. If the test indicates carbohydrate malabsorption or a lysosomal storage disease, further diagnostic testing or referrals to specialists may be required. Additionally, healthcare providers may discuss dietary modifications or treatment options to address any identified issues related to sugar metabolism. It is essential for patients to understand the implications of their test results and to engage in any recommended follow-up care to ensure optimal health outcomes.
| Short Descr | SUGARS SINGLE QUAL | Medium Descr | SUGARS MONO DI&OLIGOS 1 QUALITATAIVE EACH SPEC | Long Descr | Sugars (mono-, di-, and oligosaccharides); single qualitative, each specimen | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2011-01-01 | Changed | Short description changed. |
| 2002-01-01 | Changed | Code description changed. |
| 2001-01-01 | Changed | Code description changed. |
| 1999-01-01 | Added | First appearance in code book in 1999. |
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