CPT® Code 86308

The CPT® Code 86308 refers to a laboratory test that screens for heterophile antibodies, which are antibodies that may indicate the presence of the Epstein-Barr virus (EBV). This virus is known to cause infectious mononucleosis (IM), a condition characterized by symptoms such as fever, sore throat, swollen lymph nodes, and fatigue. The screening test, commonly known as the Infectious Mononucleosis Slide Test by LA, is typically ordered when a patient presents with clinical signs suggestive of IM. It is important to note that the test may yield negative results during the early stages of the infection, necessitating a repeat test if symptoms continue. Additionally, infants and young children generally do not produce heterophile antibodies, resulting in negative test outcomes even in cases of confirmed EBV infection. The procedure involves obtaining a blood sample through venipuncture, which is separately reportable. The serum or plasma obtained from the blood sample is then analyzed using a semiquantitative latex agglutination method to detect the presence of heterophile antibodies.