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Human leukocyte antigen (HLA) typing is a laboratory procedure that identifies specific antigens present on the surface of cells, particularly those involved in the immune response. This process focuses on the A, B, or C antigens, which are critical for determining tissue compatibility in various medical contexts. HLA typing is essential for identifying individuals who may be susceptible to certain diseases, as well as for assessing compatibility between potential organ or stem cell donors and recipients. The procedure is particularly relevant in the context of transplants, where matching HLA types can significantly influence the success of the procedure and the recipient's post-transplant health. Additionally, HLA typing plays a role in determining eligibility for specific vaccines or immunotherapy treatments, as certain HLA types may affect an individual's response to these therapies. Furthermore, HLA typing is utilized in blood transfusions to ensure platelet compatibility, thereby enhancing the survival of transfused platelets. The antigens are categorized into Class I and Class II alleles, with specific tests available for various autoimmune disorders, such as HLA-B27 DNA typing for ankylosing spondylitis. For coding purposes, the CPT® code 86812 is designated for typing a single antigen, while 86813 is used when multiple HLA antigens are assessed.
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HLA typing is performed for several specific indications, including:
The procedure for HLA typing involves several key steps, which are detailed as follows:
After the HLA typing procedure, the patient may not require any specific post-procedure care, as the process is minimally invasive and typically involves only a blood draw. However, it is important for healthcare providers to communicate the results to the patient and discuss any implications for treatment or further testing. The results can influence decisions regarding organ transplantation, eligibility for certain therapies, and management of autoimmune conditions. Patients should be informed about the timeline for receiving results, which can vary depending on the laboratory's processing capabilities.
| Short Descr | HLA TYPING A B OR C | Medium Descr | HLA TYPING A/B/C SINGLE ANTIGEN | Long Descr | HLA typing; A, B, or C (eg, A10, B7, B27), single antigen | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GA | Waiver of liability statement issued as required by payer policy, individual case | GZ | Item or service expected to be denied as not reasonable and necessary | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 77 | Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | GW | Service not related to the hospice patient's terminal condition | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | PN | Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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