CPT® Code 86812

Human leukocyte antigen (HLA) typing is a laboratory procedure that identifies specific antigens present on the surface of cells, particularly those involved in the immune response. This process focuses on the A, B, or C antigens, which are critical for determining tissue compatibility in various medical contexts. HLA typing is essential for identifying individuals who may be susceptible to certain diseases, as well as for assessing compatibility between potential organ or stem cell donors and recipients. The procedure is particularly relevant in the context of transplants, where matching HLA types can significantly influence the success of the procedure and the recipient's post-transplant health. Additionally, HLA typing plays a role in determining eligibility for specific vaccines or immunotherapy treatments, as certain HLA types may affect an individual's response to these therapies. Furthermore, HLA typing is utilized in blood transfusions to ensure platelet compatibility, thereby enhancing the survival of transfused platelets. The antigens are categorized into Class I and Class II alleles, with specific tests available for various autoimmune disorders, such as HLA-B27 DNA typing for ankylosing spondylitis. For coding purposes, the CPT® code 86812 is designated for typing a single antigen, while 86813 is used when multiple HLA antigens are assessed.