CPT® Code 87305

Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]) qualitative or semiquantitative; Aspergillus

The CPT® Code 87305 refers to a laboratory test designed to detect the presence of Aspergillus species' antigens, particularly A. fumigatus, in blood serum or plasma samples. This detection is accomplished through various immunoassay techniques, which include enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), fluorescence immunoassay (FIA), and immunochemiluminometric assay (IMCA). A. fumigatus is a type of fungus commonly found in environments such as hay, grain, decaying plant matter, and bird droppings. The infection caused by this fungus is typically airborne and poses a significant risk to individuals with compromised immune systems or damaged tissues, leading to chronic infections in the lungs, eyes, and sinuses. The immunoassay techniques employed in this test are designed to identify the specific antigens associated with the fungus, allowing for qualitative or semi-quantitative assessment of the patient's immune response to the infection. The process involves binding the Aspergillus antigen to a solid surface, followed by the introduction of the patient's serum, which contains antibodies that may react with the antigen. Subsequent steps involve washing, incubation, and the addition of enzyme-linked antibodies, culminating in a colorimetric or fluorescent reaction that indicates the presence and concentration of the antigen in the sample.