© Copyright 2026 American Medical Association. All rights reserved.
CPT® Code 88106 refers to a specific laboratory procedure known as cytopathology, which involves the examination of fluid samples, washings, or brushings, excluding those from cervical or vaginal sources. This procedure utilizes a simple filter method to isolate and analyze cells present in the sample, allowing for the interpretation of various cellular characteristics. The primary aim of this test is to diagnose a range of conditions, including malignant and premalignant diseases, infections, autoimmune disorders, inflammation, immune reactions, cellular aging, and amyloidosis. Cytopathology itself is the microscopic study of cells that either naturally exfoliate from body surfaces or can be collected through washing or brushing techniques. The samples analyzed can originate from diverse bodily fluids, such as sputum, urine, breast discharge, cerebrospinal fluid, and effusions from pleural, peritoneal, pericardial, or joint spaces, as well as vitreous fluid from the eye, skin, and gastrointestinal tract. The collection of these samples is performed through a separately reportable procedure. In the context of this code, the simple filter method is employed, where the fluid is filtered to separate the cellular components, and the resulting sediment is then fixed onto a glass slide for microscopic examination. A pathologist subsequently reviews the slide and generates a detailed written report outlining the findings of the analysis.
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