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The CPT® Code 88285 refers to a laboratory procedure specifically designed for chromosome analysis, focusing on the counting of additional cells during the study. This analysis is crucial in various medical contexts, as it helps in identifying chromosomal abnormalities that may be present in a sample. The procedure can be conducted on various biological specimens, including blood, bone marrow, solid tissues, amniotic fluid, and chorionic villi. The process begins with the collection of cells, which are then cultured to promote growth. Following this, the cells undergo a meticulous counting and sorting process. The standard protocol requires a minimum of 20 cells to be counted, with at least 5 cells and 2 karyotypes analyzed to ensure a comprehensive evaluation. In cases where structural aberrations are detected, particularly in instances of mosaicism, additional cell counts may be necessary to reach a definitive diagnosis. The use of code 88285 is specifically designated for each additional cell count study performed, highlighting its importance in the overall assessment of chromosomal integrity and abnormalities.
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The procedure associated with CPT® Code 88285 is indicated for various clinical scenarios where chromosome analysis is necessary. The following conditions may warrant this analysis:
The procedure for chromosome analysis under CPT® Code 88285 involves several critical steps to ensure accurate results. The following outlines the procedural steps:
Following the chromosome analysis procedure, there are several considerations for post-procedure care and expected outcomes. Patients may need to be monitored for any immediate reactions to the sample collection, especially if blood or bone marrow was used. The results of the chromosome analysis will typically be reviewed and interpreted by a qualified geneticist or pathologist, who will provide a detailed report. This report may include findings related to chromosomal structure and any abnormalities detected. Depending on the results, further testing or follow-up consultations may be necessary to discuss implications for the patient’s health or potential genetic counseling options.
| Short Descr | CHROMOSOME COUNT ADDITIONAL | Medium Descr | CHRMSM ANALYSIS ADDL CELLS COUNTED EACH STUDY | Long Descr | Chromosome analysis; additional cells counted, each study | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 10 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
| 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GC | This service has been performed in part by a resident under the direction of a teaching physician | GZ | Item or service expected to be denied as not reasonable and necessary | Q1 | Routine clinical service provided in a clinical research study that is in an approved clinical research study | Q4 | Service for ordering/referring physician qualifies as a service exemption | XE | Separate encounter, a service that is distinct because it occurred during a separate encounter |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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