CPT® Code 88285

The CPT® Code 88285 refers to a laboratory procedure specifically designed for chromosome analysis, focusing on the counting of additional cells during the study. This analysis is crucial in various medical contexts, as it helps in identifying chromosomal abnormalities that may be present in a sample. The procedure can be conducted on various biological specimens, including blood, bone marrow, solid tissues, amniotic fluid, and chorionic villi. The process begins with the collection of cells, which are then cultured to promote growth. Following this, the cells undergo a meticulous counting and sorting process. The standard protocol requires a minimum of 20 cells to be counted, with at least 5 cells and 2 karyotypes analyzed to ensure a comprehensive evaluation. In cases where structural aberrations are detected, particularly in instances of mosaicism, additional cell counts may be necessary to reach a definitive diagnosis. The use of code 88285 is specifically designated for each additional cell count study performed, highlighting its importance in the overall assessment of chromosomal integrity and abnormalities.