CPT® Code 88355

The CPT® Code 88355 refers to a specialized test known as morphometric analysis of skeletal muscle. This procedure involves a detailed examination of the morphometric characteristics of skeletal muscle tissue, which is primarily composed of striated fibers that work together to facilitate contraction. The analysis is crucial as it helps identify structural changes in muscle fibers and cells that may arise due to various factors, including developmental changes, nutritional status, lifestyle choices, and pathological conditions. These changes can be influenced by several hormones, such as testosterone, growth hormone, and insulin-like growth factor-1, as well as external factors like exercise, gravitational effects, and conditions such as denervation or muscle atrophy associated with aging, injury, or illness. Genetic factors, including mutations that lead to muscular dystrophies, and variations in fat content within the muscle tissue can also impact the characteristics of muscle fibers and cells. To perform this analysis, a sample of muscle tissue is obtained through a biopsy, which is reported separately. The collected tissue is then processed and analyzed using microscopic techniques and/or advanced automated or semi-automated software programs, such as MetaMorph, AxionVision, Lucia, or CyteSeer. The results of this analysis are compiled into a comprehensive written report that details the findings, providing valuable insights into the muscle's structural integrity and potential abnormalities.