CPT® Code 88358

The CPT® Code 88358 refers to a specialized laboratory procedure known as morphometric analysis, specifically focusing on tumors, such as the assessment of DNA ploidy. This procedure is conducted on tissue samples that have been previously diagnosed as malignant through histopathological examination. The primary objective of this analysis is to predict the aggressiveness of the tumor and its potential prognosis, which is crucial for guiding treatment decisions. During the process, the tissue sample is embedded in either plastic or paraffin, allowing for detailed imaging using light or fluorescent microscopy. The morphometric analysis involves collecting data from the imaged sample, which is then subjected to qualitative morphometry and computerized data reduction techniques. This comprehensive analysis provides insights into the nuclear ploidy of the chromosomes found within the cell nuclei, including the identification of specific phenotypes and receptors associated with the tumor. Morphometric analysis has proven effective in identifying DNA ploidy across various malignant neoplasms, including those affecting the liver, bile ducts, spleen, bronchus, lungs, breast, prostate, kidney, bladder, and adrenal glands. Additionally, it is utilized in the evaluation of secondary neoplasms in organs such as the lungs, adrenal glands, large intestine, rectum, liver, and other digestive and urinary organs, as well as in the breast and genital organs. The procedure is also applicable in assessing carcinoma in situ in the colon, liver, bile ducts, and other digestive organs, along with conditions like non-Hodgkin’s lymphoma, esophageal ulcers, regional enteritis, and ulcerative colitis.