CPT® Code 88381

Microdissection is a specialized technique used to isolate and prepare specific cells from a tissue sample for detailed examination. In the context of CPT® Code 88381, this procedure involves the manual separation of microscopically identified target cells. The process is crucial for studying disease at a cellular level, allowing pathologists to analyze the characteristics of abnormal or neoplastic cells in comparison to normal tissue. During the procedure, a thin section of tissue is placed under a dissecting microscope, where the pathologist can visually identify clusters of cells of interest. Using precise instruments such as a razor blade or scalpel, the pathologist manually dissects and extracts these targeted cells. This meticulous approach ensures that the selected cells are preserved for further analysis, which can provide valuable insights into the nature of the disease and inform treatment decisions. The manual technique described in CPT® Code 88381 is essential for cases where laser capture methods are not applicable or when a more hands-on approach is required to obtain the necessary cellular samples.