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Official Description

Biopsy, oocyte polar body or embryo blastomere, microtechnique (for pre-implantation genetic diagnosis); less than or equal to 5 embryos

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 89290 involves the biopsy of oocyte polar bodies or embryo blastomeres using microtechniques specifically for pre-implantation genetic diagnosis (PGD). This procedure is crucial for patients who are known carriers of specific genetic diseases, as it allows for the identification of genetically normal oocytes or embryos prior to implantation. The process begins with a microscopic examination of the oocyte to assess its maturity if the biopsy is performed on an oocyte. In cases where the biopsy is conducted on an embryo, the viability of the embryo is also evaluated. During the procedure, the oocyte or embryo is carefully held in place with a holding pipette while being observed under a microscope. A small incision is made in the oocyte or embryo using either a mechanical or enzymatic method. Following this, a biopsy pipette is utilized to extract one or two polar bodies or blastomeres, which are then sent for separate genetic analysis. This code is applicable when the biopsy involves five or fewer oocytes or embryos, while a different code, CPT® Code 89291, is designated for procedures involving more than five oocytes or embryos.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure coded as CPT® 89290 is indicated for patients who are known carriers of certain genetic diseases. The primary purpose of this biopsy is to identify genetically normal oocytes or embryos, which is essential for couples undergoing in vitro fertilization (IVF) who wish to minimize the risk of passing on genetic disorders to their offspring.

  • Genetic Carrier Status Patients who are carriers of specific genetic conditions may undergo this procedure to ensure that only genetically normal embryos are selected for implantation.
  • Pre-implantation Genetic Diagnosis This procedure is performed as part of the pre-implantation genetic diagnosis process to assess the genetic health of embryos before they are implanted into the uterus.

2. Procedure

The procedure involves several critical steps to ensure the successful biopsy of oocyte polar bodies or embryo blastomeres.

  • Step 1: Microscopic Examination Initially, the oocyte is examined microscopically to determine its maturity. If the biopsy is performed on an embryo, the viability of the embryo is assessed at this stage to ensure that only healthy embryos are selected for genetic analysis.
  • Step 2: Holding the Oocyte or Embryo Once the oocyte or embryo is deemed suitable for biopsy, it is carefully grasped using a holding pipette. This pipette stabilizes the specimen while it is viewed under a microscope, allowing for precise manipulation during the biopsy process.
  • Step 3: Creating an Opening A small hole is created in the oocyte or embryo using either a mechanical or enzymatic technique. This step is crucial as it allows access to the polar bodies or blastomeres that need to be biopsied.
  • Step 4: Biopsy Procedure After the opening is made, a biopsy pipette is employed to remove one or two polar bodies or blastomeres from the oocyte or embryo. This sample is then prepared for separate genetic analysis, which will help determine the genetic health of the embryos.

3. Post-Procedure

Post-procedure care typically involves monitoring the patient for any immediate complications following the biopsy. The extracted polar bodies or blastomeres are sent for genetic analysis, and the results will guide the selection of embryos for implantation. Patients may be advised on the next steps in their fertility treatment plan based on the outcomes of the genetic testing. It is essential for healthcare providers to communicate the results effectively and discuss the implications for future pregnancies.

Short Descr BIOPSY OOCYTE POLAR BODY <=5
Medium Descr BX OOCYTE POLR BDY/EMBRY BLST MICROTQ <= 5 EMBRY
Long Descr Biopsy, oocyte polar body or embryo blastomere, microtechnique (for pre-implantation genetic diagnosis); less than or equal to 5 embryos
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator STV-Packaged Codes
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
Date
Action
Notes
2024-01-01 Changed Short and Medium Descriptions changed.
2013-01-01 Changed Medium Descriptor changed.
2011-01-01 Changed Short description changed.
2004-01-01 Added First appearance in code book in 2004.
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